Guide

Phase I to III natural health product trial: obtain the notice of authorization before the first participant

Phase I to III natural health product trial: obtain the notice of authorization before the first participant

Priority

Research ethics approval alone does not allow the trial to start. Each site must be ready and the sponsor must obtain written regulatory authorization.

Confirm the scope

Confirm the product, investigational use and phase fall under the natural health product regulations and identify the sponsor.

Prepare the information

Prepare the protocol, brochure, consent, quality data, synopsis, sites, investigators, ethics board and safety information.

Complete the process

Complete the application and attestation, site forms and undertakings, then submit the electronic package through the current channel.

Keep follow-up records

Await the authorization notice and ethics approvals, then manage amendments, reactions, records, inspection and result disclosure.

Natural health product clinical trial forms — Health Canada

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Official sources are linked in the guide. Checked August 30, 2026; confirm current rules, forms and deadlines with the responsible authority.
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